Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.64 |
| ▸ | CDK4 | P11802 | 13/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.64 |
| ▸ | CCND1 | P24385 | 13/20 | 0.64 |
| ▸ | CCND3 | P30281 | 13/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.64 |
| ▸ | KDR | P35968 | 6/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.64 |
| ▸ | TYK2 | P29597 | 3/20 | 0.64 |
| ▸ | JAK3 | P52333 | 3/20 | 0.64 |
| ▸ | JAK1 | P23458 | 2/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 3/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951869 | 0.84 | FGFR1 (0.60) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5508107 | 0.83 | CDK4 (0.60) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5952183 | 0.83 | FGFR1 (0.61) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5952893 | 0.82 | FGFR1 (0.57) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5952685 | 0.82 | FGFR1 (0.63) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL4919287 | 0.81 | FGFR1 (0.66) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5953064 | 0.81 | FGFR1 (0.69) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5951323 | 0.80 | FGFR1 (0.64) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5248844 | 0.78 | CDK4 (1.00) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5952586 | 0.78 | ITK (0.69) | CDK2CDK4CCNA2CCND1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | claimed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | claimed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | claimed |
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | disclosed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | CDK9, BMX, SBK3 | CDK2 12/4885CDK4 44/4885CCNA2 606/4885 |
| US-20040048868-A1 | Benzimidazoles | CDK9, BMX, CDKN1A | CDK2 13/4885CDK4 51/4885CCNA2 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.