Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 5/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951902 | 0.89 | RET (0.48) | HDAC6PDE10ASCDRETFADS1 | |
| SCHEMBL4916396 | 0.88 | PDE10A (0.53) | PDE10ASCDRETCYP1A2CYP3A4 | |
| SCHEMBL5952146 | 0.88 | PDE10A (0.53) | PDE10ASCDRETCYP1A2CYP3A4 | |
| SCHEMBL5952104 | 0.85 | NPC1 (0.52) | PDE10ARETSMN1; SMN2ERBB2CDK1 | |
| SCHEMBL5952574 | 0.83 | CACNA1B (0.46) | PDE10ARETCYP3A4LMNAHPGD | |
| SCHEMBL5953158 | 0.81 | PDE10A (0.51) | PDE10AHPGDSMN1; SMN2KDRKDM4E | |
| SCHEMBL5953027 | 0.81 | CDK4 (0.61) | PDE10ASCDSMN1; SMN2KDRF9 | |
| SCHEMBL5952578 | 0.81 | MEN1 (0.51) | PDE10ASCDCYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL5952326 | 0.81 | NMT1 (0.50) | PDE10ARETSMN1; SMN2ERBB2CDK1 | |
| SCHEMBL5953232 | 0.80 | ITK (0.52) | PDE10ASCDSMN1; SMN2KDRDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518100-B1 | HYDROPHILIC POLYMER COMPOUND HAVING ANTICOAGULATION EFFECT | TORAY INDUSTRIES (JP) | 2015-02-18 | — | — | EP | claimed |
| US-20140142613-A1 | INSTRUMENT FOR CAPTURING FREE THROMBI | TORAY INDUSTRIES, INC. (JP) | 2014-05-22 | — | — | US | claimed |
| US-20140121181-A1 | HYDROPHOBIC POLYMER COMPOUND HAVING ANTICOAGULANT EFFECT | TORY INDUSTRIES, INC. (JP) | 2014-05-01 | — | — | US | claimed |
| EP-2724733-A1 | HYDROPHOBIC POLYMER COMPOUND HAVING ANTICOAGULANT EFFECT | Toray Industries, Inc. (JP) | 2014-04-30 | — | — | EP | claimed |
| EP-2724735-A1 | MEDICAL SUPPLY | Toray Industries, Inc. (JP) | 2014-04-30 | — | — | EP | claimed |
| EP-2724732-A1 | INSTRUMENT FOR CAPTURING FREE THROMBI | Inoue, Kanji (JP) | 2014-04-30 | — | — | EP | claimed |
| US-20140113091-A1 | MEDICAL SUPPLY | TORAY INDUSTRIES, INC. (JP) | 2014-04-24 | — | — | US | claimed |
| EP-2518100-A1 | HYDROPHILIC POLYMER COMPOUND HAVING ANTICOAGULATION EFFECT | Toray Industries, Inc. (JP) | 2012-10-31 | — | — | EP | claimed |
| US-20120271010-A1 | HYDROPHILIC POLYMER COMPOUND HAVING ANTICOAGULATION EFFECT | TORAY INDUSTRIES, INC. (JP) | 2012-10-25 | — | — | US | claimed |
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | claimed |
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |
| EP-0608831-B1 | Compositions containing argatroban analogs | MITSUBISHI CHEM CORP (JP) | 2000-03-22 | — | — | EP | claimed |
| EP-0608828-B1 | Compositions containing argatroban analogs | MITSUBISHI CHEM CORP (JP) | 2000-03-22 | — | — | EP | claimed |
| US-5565471-A | Method for inhibiting thrombosis | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-10-15 | — | — | US | claimed |
| EP-0608828-A1 | Compositions containing argatroban analogs | Mitsubishi Chemical Corporation (JP) | 1994-08-03 | — | — | EP | claimed |
| EP-0608831-A1 | Compositions containing argatroban analogs | Mitsubishi Chemical Corporation (JP) | 1994-08-03 | — | — | EP | claimed |
| US-5141947-A | N2-Arylsulfonyl-L-arginien amide derivatives | MITSUBISHI KASEI CORPORATION (JP) | 1992-08-25 | — | — | US | claimed |
| EP-0181267-B1 | FIBRINOLYSIS-ENHANCING AGENTS | MITSUBISHI KASEI CORPORATION (JP) | 1991-05-08 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | CDK9, BMX, SBK3 | HDAC6 137/4885PDE10A 294/4885SCD 4306/4885 |
| US-20040048868-A1 | Benzimidazoles | CDK9, BMX, CDKN1A | HDAC6 198/4885PDE10A 451/4885SCD 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.