Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.49 |
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954211 | 0.92 | AURKA (0.51) | AURKAAURKBITKPDPK1CHEK1 | |
| SCHEMBL4888848 | 0.92 | AURKA (0.52) | AURKAAURKBITKPDPK1CHEK1 | |
| SCHEMBL4893770 | 0.90 | ITK (0.52) | AURKAAURKBITKBRD4CHEK1 | |
| SCHEMBL4892853 | 0.88 | AURKA (0.51) | AURKAAURKBITKBRD4PDPK1 | |
| SCHEMBL4897206 | 0.86 | ITK (0.50) | AURKAAURKBITKBRD4PDPK1 | |
| SCHEMBL5954138 | 0.85 | AURKA (0.52) | AURKAAURKBITKPDPK1CHEK1 | |
| SCHEMBL4895079 | 0.82 | AURKA (0.47) | AURKAAURKBITKPDPK1CHEK1 | |
| SCHEMBL5954682 | 0.81 | AURKA (0.45) | AURKAAURKBITKBRD4PDPK1 | |
| SCHEMBL4890270 | 0.81 | AURKA (0.46) | AURKAAURKBITKBRD4PDPK1 | |
| SCHEMBL4887900 | 0.81 | AURKA (0.56) | AURKAAURKBPDPK1CHEK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142247-A1 | Tricyclic heterocycles | HOFFMANN-LA ROCHE INC. | 2006-06-29 | — | — | US | claimed |
| US-20060142247-A1 | Tricyclic heterocycles | HOFFMANN-LA ROCHE INC. | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142247-A1 | Tricyclic heterocycles | CYP11B1, CYP11B2, CYP3A43 | AURKA 2529/4885AURKB 2155/4885ITK 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.