Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 19/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954692 | 0.92 | FLT3 (0.49) | FLT3AURKAAURKB | |
| SCHEMBL4895119 | 0.92 | AURKA (0.48) | FLT3AURKAAURKB | |
| SCHEMBL4888262 | 0.92 | AURKA (0.48) | FLT3AURKAAURKB | |
| SCHEMBL5190165 | 0.91 | AURKA (0.47) | FLT3AURKAAURKB | |
| SCHEMBL5954707 | 0.90 | AURKA (0.47) | FLT3AURKAAURKB | |
| SCHEMBL5955008 | 0.90 | AURKA (0.46) | FLT3AURKAAURKB | |
| SCHEMBL5954209 | 0.90 | AURKA (0.46) | FLT3AURKAAURKB | |
| SCHEMBL5954302 | 0.89 | AURKA (0.47) | FLT3AURKAAURKB | |
| SCHEMBL5954822 | 0.88 | AURKA (0.46) | FLT3AURKAAURKB | |
| SCHEMBL5954827 | 0.86 | AURKA (0.54) | FLT3AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142247-A1 | Tricyclic heterocycles | HOFFMANN-LA ROCHE INC. | 2006-06-29 | — | — | US | claimed |
| US-20060142247-A1 | Tricyclic heterocycles | HOFFMANN-LA ROCHE INC. | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142247-A1 | Tricyclic heterocycles | CYP11B1, CYP11B2, CYP3A43 | FLT3 809/4885AURKA 2529/4885AURKB 2155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.