SCHEMBL5954935

SCHEMBL5954935

O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Cl)N2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 20/20 1.00
CXCR1 P25024 7/20 1.00
CYP2C9 P11712 1/20 1.00
SERPINE1 P05121 1/20 0.71
ADRA1D P25100 1/20 0.71
ADORA2A P29274 1/20 0.71
HTR7 P34969 1/20 0.71
ADRA1A P35348 1/20 0.71
ADRA1B P35368 1/20 0.71
MAPK14 Q16539 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29843937 1.00 CXCR2 (1.00) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL5954897 0.88 CXCR2 (1.00) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL4686262 0.87 CXCR2 (0.75) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL5954904 0.86 CXCR2 (0.75) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL4698274 0.85 CXCR2 (0.74) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL4687691 0.85 CXCR2 (1.00) CXCR2CXCR1CYP2C9
SCHEMBL5954354 0.83 CXCR2 (1.00) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL5955084 0.80 CXCR2 (1.00) CXCR2CXCR1CYP2C9
SCHEMBL4648882 0.78 CXCR2 (0.64) CXCR2CXCR1CYP2C9SERPINE1ADRA1D
SCHEMBL4687748 0.77 CXCR2 (0.60) CXCR2CXCR1CYP2C9SERPINE1ADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4686469-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF DIABETES-ASSOCIATED COMORBIDITIES Dompé farmaceutici SpA (IT) 2026-02-04 EP claimed
EP-4686472-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE Dompé farmaceutici SpA (IT) 2026-02-04 EP claimed
EP-4678171-A1 SYSTEMICALLY-ADMINISTERED CXCL8 INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID Dompé farmaceutici SpA (IT) 2026-01-14 EP claimed
EP-4563594-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF TUMORS WITH LOW STROMAL CAV1 LEVELS Dompe' Farmaceutici SpA (IT) 2025-06-04 EP claimed
EP-4397305-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID Dompe' Farmaceutici S.P.A. (IT) 2024-07-10 EP claimed
US-20240156757-A1 CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES DOMPE' FARMACEUTICI SPA (IT) 2024-05-16 US claimed
EP-4052702-A1 CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES Dompé farmaceutici S.p.a. (IT) 2022-09-07 EP claimed
WO-2017098421-A1 BENZOTHIADIAZINE COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-06-15 WO claimed
US-20060122173-A1 Il-8 receptor antagonists BUSCH-PETERSEN JAKOB 2006-06-08 US claimed
EP-4686469-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF DIABETES-ASSOCIATED COMORBIDITIES Dompé farmaceutici SpA (IT) 2026-02-04 EP disclosed
EP-4686472-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE Dompé farmaceutici SpA (IT) 2026-02-04 EP disclosed
EP-4678171-A1 SYSTEMICALLY-ADMINISTERED CXCL8 INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID Dompé farmaceutici SpA (IT) 2026-01-14 EP disclosed
EP-4563594-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF TUMORS WITH LOW STROMAL CAV1 LEVELS Dompe' Farmaceutici SpA (IT) 2025-06-04 EP disclosed
US-20250161248-A1 Treating Chronic Myelomonocytic Leukemia with CXCL8 Receptor Inhibitors INSTITUT GUSTAVE ROUSSY (FR) 2025-05-22 US disclosed
EP-4397305-A1 CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF OCULAR MUCOUS MEMBRANE PEMPHIGOID AND/OR ORAL MUCOUS MEMBRANE PEMPHIGOID Dompe' Farmaceutici S.P.A. (IT) 2024-07-10 EP disclosed
US-20240156757-A1 CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES DOMPE' FARMACEUTICI SPA (IT) 2024-05-16 US disclosed
EP-4052702-A1 CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES Dompé farmaceutici S.p.a. (IT) 2022-09-07 EP disclosed
WO-2017098421-A1 BENZOTHIADIAZINE COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-06-15 WO disclosed
US-20060122173-A1 Il-8 receptor antagonists BUSCH-PETERSEN JAKOB 2006-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060122173-A1 Il-8 receptor antagonists CXCL8, CCR8, IL1RN CXCR2 9/4885CXCR1 13/4885CYP2C9 1613/4885
US-20250161248-A1 Treating Chronic Myelomonocytic Leukemia with CXCL8 Receptor Inhibitors CXCL8, CCR8, CSF3R CXCR2 5/4885CXCR1 15/4885CYP2C9 4205/4885
US-20240156757-A1 CXCL8 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF FOR USE IN THE TREATMENT OF SEIZURES CXCL8, CCR8, CXCL10 CXCR2 8/4885CXCR1 12/4885CYP2C9 822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.