Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957101 | 0.92 | DRD2 (0.41) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957077 | 0.92 | DRD2 (0.41) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957050 | 0.92 | DRD2 (0.52) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957097 | 0.91 | DRD2 (0.41) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957114 | 0.84 | DRD2 (0.43) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957093 | 0.83 | DRD2 (0.42) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957052 | 0.82 | DRD2 (0.41) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957116 | 0.82 | DRD2 (0.52) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957067 | 0.82 | DRD2 (0.41) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5957135 | 0.81 | DRD2 (0.51) | DRD2DRD4DRD3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | claimed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |