Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957134 | 0.83 | DRD2 (0.47) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL5957139 | 0.82 | DRD2 (0.55) | DRD2DRD4DRD3SLC6A4HTR2A | |
| Aplindore SCHEMBL3192098 | 0.82 | DRD2 (0.68) | DRD2DRD4DRD3SLC6A4HTR2A | |
| Aplindore SCHEMBL119499 | 0.82 | DRD2 (0.68) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL5957105 | 0.82 | DRD2 (0.51) | DRD2DRD4DRD3SLC6A4HTR2A | |
| Aplindore SCHEMBL29359212 | 0.82 | DRD2 (0.68) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL5957098 | 0.82 | DRD2 (0.48) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL13222379 | 0.81 | DRD2 (0.42) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL5957081 | 0.80 | DRD2 (0.55) | DRD2DRD4DRD3SLC6A4HTR2A | |
| SCHEMBL5957085 | 0.80 | DRD2 (0.44) | DRD2DRD4DRD3SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | claimed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |