Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 4/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17430152 | 0.89 | MAPT (0.49) | MAPTMAOBGSK3BDYRK1AKDM4E | |
| SCHEMBL17432449 | 0.88 | MAPT (0.46) | MAPTMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL17432481 | 0.81 | MAPT (0.49) | MAPTMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL10049511 | 0.80 | ESR2 (0.49) | MAPTMAOBGSK3BDYRK1ACDK9 | |
| SCHEMBL17432446 | 0.80 | MAPT (0.46) | MAPTMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL17430154 | 0.79 | MAPT (0.49) | MAPTMAOBGSK3BDYRK1AKDM4E | |
| SCHEMBL17432475 | 0.79 | PAX8 (0.45) | MAPTMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL17430110 | 0.78 | MAPT (0.45) | MAPTMAOBGSK3BDYRK1ACDK9 | |
| SCHEMBL17432478 | 0.78 | MAPT (0.43) | MAPTMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL17430151 | 0.77 | MAPT (0.55) | MAPTMAOBGSK3BDYRK1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701637-B2 | Tau imaging probe | GE HEALTHCARE LIMITED (GB) | 2017-07-11 | — | — | US | disclosed |
| US-9452985-B2 | Tau imaging probe | GE HEALTHCARE LIMITED (GB) | 2016-09-27 | — | — | US | disclosed |
| US-20160271278-A1 | TAU IMAGING PROBE | GE HEALTHCARE LTD (GB) | 2016-09-22 | — | — | US | disclosed |
| US-9249101-B2 | Tau imaging probe | CLINO LTD. (JP) | 2016-02-02 | — | — | US | disclosed |
| US-20160008494-A1 | TAU IMAGING PROBE | GE HEALTHCARE LIMITED (GB) | 2016-01-14 | — | — | US | disclosed |
| WO-2012057312-A1 | TAU IMAGING PROBE | クリノ株式会社 (JP) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160008494-A1 | TAU IMAGING PROBE | MAPT, APP, APBA1 | MAPT 1/4885MAOB 2859/4885GSK3B 65/4885 |
| US-20160271278-A1 | TAU IMAGING PROBE | MAPT, APP, APBA1 | MAPT 1/4885MAOB 2859/4885GSK3B 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.