Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | RECQL | P46063 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359598 | 0.72 | GAA (0.52) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL1030769 | 0.70 | KDM4E (0.41) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL6120953 | 0.69 | GAA (0.43) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL14041780 | 0.69 | GAA (0.43) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL423483 | 0.68 | MAPT (0.68) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL6060912 | 0.68 | RAB9A (0.47) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL5027456 | 0.65 | MEN1 (0.63) | GAAKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7221535 | 0.65 | KDM4A (0.41) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL14188119 | 0.64 | KDM4E (0.48) | GAAKDM4ERECQLALDH1A1MAPT | |
| SCHEMBL4160754 | 0.64 | KDM4E (0.54) | GAAKDM4ERECQLALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709019-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068444-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-07-28 | — | — | WO | disclosed |