Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 2/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.61 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SHBG | P04278 | 2/20 | 0.42 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528354 | 1.00 | G6PD (0.69) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL8640096 | 1.00 | G6PD (0.69) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL9764804 | 1.00 | G6PD (0.69) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL502481 | 0.85 | CYP19A1 (0.63) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL502482 | 0.85 | CYP19A1 (0.63) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL502634 | 0.85 | CYP19A1 (0.63) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL15094423 | 0.85 | CYP19A1 (0.63) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL5312818 | 0.84 | CYP19A1 (0.61) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL502992 | 0.84 | CYP19A1 (0.61) | G6PDCYP19A1HSD17B3GPBAR1LMNA | |
| SCHEMBL503217 | 0.84 | CYP19A1 (0.61) | G6PDCYP19A1HSD17B3GPBAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934745-B1 | Use of androsterone derivatives for inhibiting DNA binding of ap-1 and airway smooth muscle proliferation | CHARLOTTE MECKLENBURG HOSPITAL (US) | 2004-04-28 | — | — | EP | claimed |
| EP-0934745-A1 | Use of androsterone derivatives for inhibiting DNA binding of ap-1 and airway smooth muscle proliferation | CHARLOTTE-MECKLENBURG HOSPITAL doing business as Carolinas Medical Center (US) | 1999-08-11 | — | — | EP | claimed |
| JP-2006342180-A | CHRONIC ASTHMA MEDICINE CONTAINING ANDROSTERONE DERIVATIVE | CHARLOTTE MECKLENBURG HOSPITAL DOING AS CAROLINAS MEDICAL CENTER | 2006-12-21 | — | — | JP | disclosed |
| EP-0934745-B1 | Use of androsterone derivatives for inhibiting DNA binding of ap-1 and airway smooth muscle proliferation | CHARLOTTE MECKLENBURG HOSPITAL (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-0934745-A1 | Use of androsterone derivatives for inhibiting DNA binding of ap-1 and airway smooth muscle proliferation | CHARLOTTE-MECKLENBURG HOSPITAL doing business as Carolinas Medical Center (US) | 1999-08-11 | — | — | EP | disclosed |
| EP-0934745-A1 | Use of androsterone derivatives for inhibiting DNA binding of ap-1 and airway smooth muscle proliferation | CHARLOTTE-MECKLENBURG HOSPITAL doing business as Carolinas Medical Center (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5804576-A | CANCER PREVENTIVE AGENTS, ANTI-OBESITY AGENTS, TREATMENT OF DIABETES | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-09-08 | — | — | US | disclosed |
| US-5744462-A | ADMINISTERING GLUCOSE-6-PHOSPHATE DEHYDROGENASE INHIBITOR | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-04-28 | — | — | US | disclosed |
| US-5714481-A | ADMINISTERING TO MAMMALIAN HOST A GLUCOSE-6-PHSOPHATE DEHYDROGENASE INHIBITOR, ANTICARCINOGENIC, ANTIOBASITY, ANTI-HYPERGLYCEMIC, ANTIAGING, ANTICHOLESTEROL AND ANTI-AUTOIMMUNE AGENT | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| US-5700793-A | AN ANDROSTANE-17-ONE AND ENE STEROIDS; HYPOGLYCEMIC AGENT, ANTICHOLESTEROL AGENT; TREATING AUTOIMMUNE DISEASES | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| US-5696106-A | Steroids useful as anti-cancer and anti-obesity agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| US-5656621-A | ADMINISTERING ANTIDIABETIC, ANTIAGING, ANTIHYPERCHOLESTROLEMIC, ANTIHYPERGLYCEMIC AGENT | RESEARCH CORPORATION TECH., INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5175154-A | Antiobesity, antidiabetic, antilipemic, anticholesterol agents | RESEARCH CORPORATION TECHNOLOGIES, INC. | 1992-12-29 | — | — | US | disclosed |
| US-5157031-A | Androsterone derivatives | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0246650-B1 | STEROIDS USEFUL AS ANTI-CANCER AND ANTI-OBESITY AGENTS, A THERAPEUTIC COMPOSITION CONTAINING THEM AND USE THEREOF FOR THE PREPARATION OF A THERAPEUTIC COMPOSITION | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1992-01-02 | — | — | EP | disclosed |
| US-5028631-A | Anticancer, antiobesity, anticholesterol | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1991-07-02 | — | — | US | disclosed |
| US-5001119-A | 16-substituted androstanes and 16-substituted androstenes | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1991-03-19 | — | — | US | disclosed |
| US-4898694-A | 17-Hydroxy-steroids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1990-02-06 | — | — | US | disclosed |