Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.83 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL2005530 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL30692300 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Tartaric Acid SCHEMBL29368126 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL218603 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL41453 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL30692284 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL9602705 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL41454 | 0.96 | TSHR (0.91) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL5961170 | 0.92 | TSHR (0.83) | TSHRTP53CYP2C9PDE4ACYP2C19 | |
| Cadaverine Tartrate SCHEMBL1938732 | 0.92 | TSHR (0.83) | TSHRTP53CYP2C9PDE4ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049466-B2 | Contacting in reaction zone an alkane with a catalyst containing a mixed metal oxide under conditions which produce product gas comprising unsaturated carboxylic acid, unreacted alkane and alkene | ROHM AND HAAS COMPANY (US) | 2006-05-23 | — | — | US | disclosed |
| US-6989460-B2 | Methods for producing unsaturated carboxylic acids and unsaturated nitriles | ROHM AND HAAS COMPANY (US) | 2006-01-24 | — | — | US | disclosed |
| US-20040210086-A1 | Methods for producing unsaturated carboxylic acids and unsaturated nitriles | BOGAN LEONARD EDWARD (US) | 2004-10-21 | — | — | US | disclosed |
| US-6710207-B2 | CATALYTIC OXIDATION OF MIXTURES OF ALKENES AND ALKANES IN PRESENCE OF MIXED METAL OXIDE CONTAINING MOLYBDENUM OR TUNGSTEN | ROHM AND HAAS COMPANY | 2004-03-23 | — | — | US | disclosed |
| US-20030187297-A1 | Methods for producing unsaturated carboxylic acids and unsaturated nitriles | ROHM AND HAAS COMPANY | 2003-10-02 | — | — | US | disclosed |
| US-20020123647-A1 | Recycle process | ROHM AND HAAS COMPANY | 2002-09-05 | — | — | US | disclosed |
| EP-1201636-A2 | Method for producing unsaturated carboxylic acids and unsaturated nitriles | ROHM AND HAAS COMPANY (US) | 2002-05-02 | — | — | EP | disclosed |
| EP-1193240-A1 | Recycle process in the preparation of unsaturated carboxylic acids from alkane | ROHM AND HAAS COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0529853-B1 | Catalyst and process for producing nitriles | MITSUBISHI CHEM CORP (JP) | 1996-02-28 | — | — | EP | disclosed |
| US-5472925-A | Coordination catalysts for producing a nitrile from an alkane comprising an oxide of molybdenum, vanadium, tellurium and one other metal; calcining in oxygen-free; catalyst selectivity | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-12-05 | — | — | US | disclosed |
| US-5281745-A | Catayltic oxidation of an alkane and ammonia to prepare alpha, beta-ethylenically unsaturated nitrile | MITSUBISHI KASEI CORPORATION (JP) | 1994-01-25 | — | — | US | disclosed |
| EP-0529853-A2 | Catalyst and process for producing nitriles | Mitsubishi Chemical Corporation (JP) | 1993-03-03 | — | — | EP | disclosed |