Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27873444 | 0.87 | POLB (0.49) | ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5961340 | 0.86 | MEN1 (0.52) | L3MBTL1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1010372 | 0.79 | PTGDR2 (0.41) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL3048489 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL25304122 | 0.73 | ALDH1A1 (0.73) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL11183813 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL28362194 | 0.72 | POLB (0.62) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL94347 | 0.72 | ALDH1A1 (0.55) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL10490780 | 0.72 | KMT2A (0.59) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL87044 | 0.72 | POLB (0.61) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006524645-A | — | — | 2006-11-02 | — | — | JP | claimed |
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | claimed |