Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.76 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.58 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL594868 | 0.89 | DGAT1 (0.84) | DGAT1SOAT2SOAT1 | |
| SCHEMBL596301 | 0.88 | DGAT1 (0.77) | DGAT1 | |
| SCHEMBL595385 | 0.88 | DGAT1 (0.75) | DGAT1SOAT2SOAT1 | |
| SCHEMBL595084 | 0.88 | DGAT1 (0.77) | DGAT1 | |
| Hydrochloric Acid SCHEMBL596010 | 0.87 | DGAT1 (0.75) | DGAT1 | |
| SCHEMBL594894 | 0.86 | DGAT1 (0.75) | DGAT1SOAT2SOAT1 | |
| Trifluoroacetic Acid SCHEMBL596350 | 0.86 | DGAT1 (0.74) | DGAT1 | |
| SCHEMBL10272338 | 0.86 | DGAT1 (0.71) | DGAT1SOAT2SOAT1 | |
| SCHEMBL28809629 | 0.86 | DGAT1 (0.83) | DGAT1SOAT2SOAT1 | |
| SCHEMBL27817685 | 0.85 | DGAT1 (0.70) | DGAT1SOAT2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153644-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8115011-B2 | (S)-3-{5-[(1-Pyridin-2-yl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester; obesity, type II diabetes mellitus and metabolic syndrome | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8058299-B2 | Diacylglycerol acyltransferase inhibitors | VIA PHARMACEUTICALS, INC. (US) | 2011-11-15 | — | — | US | disclosed |