Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961503 | 0.79 | CCR2 (0.52) | CCR2CCR5S1PR1ADRB2GPR183 | |
| Hydrochloric Acid SCHEMBL5961486 | 0.78 | CCR2 (0.51) | CCR2CCR5S1PR1ADRB2GPR183 | |
| SCHEMBL5961451 | 0.77 | CCR2 (0.46) | CCR2CCR5S1PR1ADRB2GPR183 | |
| Hydrochloric Acid SCHEMBL5961464 | 0.77 | CCR2 (0.46) | CCR2CCR5S1PR1ADRB2GPR183 | |
| SCHEMBL5961430 | 0.74 | CCR2 (0.49) | CCR2CCR5S1PR1CSF1RPDGFRA | |
| Hydrochloric Acid SCHEMBL5961437 | 0.74 | CCR2 (0.49) | CCR2CCR5S1PR1CSF1RPDGFRA | |
| SCHEMBL5961429 | 0.68 | CCR2 (0.47) | CCR2CCR5S1PR1CSF1RFLT3 | |
| SCHEMBL5961506 | 0.67 | CCR2 (0.58) | CCR2CCR5CSF1RFLT4FLT3 | |
| Hydrochloric Acid SCHEMBL5961557 | 0.67 | CCR2 (0.57) | CCR2CCR5CSF1RFLT4FLT3 | |
| SCHEMBL5961476 | 0.64 | CCR2 (0.76) | CCR2CCR5S1PR1ADRB2GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992086-B2 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. (US) | 2006-01-31 | — | — | US | disclosed |