Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16757063 | 0.93 | TDP1 (0.57) | TDP1 | |
| SCHEMBL15769635 | 0.89 | TDP1 (0.64) | TDP1 | |
| SCHEMBL6393609 | 0.89 | TDP1 (0.64) | TDP1 | |
| SCHEMBL15783533 | 0.89 | TDP1 (0.64) | TDP1 | |
| SCHEMBL15783526 | 0.89 | TDP1 (0.64) | TDP1 | |
| SCHEMBL15783527 | 0.89 | TDP1 (0.64) | TDP1 | |
| Hydrochloric Acid SCHEMBL16143332 | 0.87 | TDP1 (0.62) | TDP1 | |
| SCHEMBL12714711 | 0.86 | TDP1 (0.55) | TDP1 | |
| SCHEMBL11529203 | 0.86 | TDP1 (0.61) | TDP1 | |
| SCHEMBL12714714 | 0.86 | TDP1 (0.61) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992086-B2 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-0731090-B1 | Process for the production of 3,(4)-substituted pyrrolidines | BAYER MATERIALSCIENCE AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| EP-0499873-B1 | Use of 3,(4)-substituted pyrrozidines as catalysts in the polyisocyanate-polyaddition process and a process for the preparation of polyurethanes and polyureas | BAYER AG (DE) | 2000-11-22 | — | — | EP | disclosed |
| US-5627190-A | TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION, ORGASTROINTESTINAL DISORDERS, 5-HYDROXYTRYPTAMINE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0731090-A2 | Process for the production of 3,(4)-substituted pyrrolidines | BAYER AG (DE) | 1996-09-11 | — | — | EP | disclosed |
| EP-0417746-B1 | N-Azabicyclo/3.3.0/octane amides of aromatic acids | SEARLE & CO (US) | 1994-11-23 | — | — | EP | disclosed |
| US-5318977-A | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G. D. SEARLE & CO. (US) | 1994-06-07 | — | — | US | disclosed |
| WO-1994000454-A1 | BENZIMIDAZOLE COMPOUNDS | G.D. SEARLE & CO. (US) | 1994-01-06 | — | — | WO | disclosed |
| US-5274114-A | Preparation and use of 3, (4)-substituted pyrrolidines as catalysts for the polyisocyanate polyaddition process | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0528026-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0499873-A2 | Use of 3,(4)-substituted pyrrozidines as catalysts in the polyisocyanate-polyaddition process, process for their preparation and a process for the preparation of polyurethanes and polyureas | BAYER AG (DE) | 1992-08-26 | — | — | EP | disclosed |
| US-5126343-A | Antiserotonine agents; gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1992-06-30 | — | — | US | disclosed |
| EP-0417746-A2 | N-Azabicyclo/3.3.0/octane amides of aromatic acids | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4992461-A | Treating gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0345712-A1 | Pyrrolizine derivate and its manufacture | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-12-13 | — | — | EP | disclosed |