Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | FRK | P42685 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5962308 | 1.00 | MAPK14 (0.51) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL5962380 | 0.80 | MAPK14 (0.57) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL5962354 | 0.79 | PIK3CA (0.47) | MAPK14GSK3BDYRK1A | |
| SCHEMBL5962454 | 0.79 | MAPK13 (0.54) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL5962367 | 0.79 | MAPK13 (0.54) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL6808788 | 0.73 | MAPK14 (0.56) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL27597808 | 0.72 | MAPK13 (0.59) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL5769819 | 0.72 | MAPK14 (0.55) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL7188681 | 0.72 | MAPK14 (0.53) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL4114860 | 0.71 | EIF2AK2 (0.54) | MAPK14MAPK13GSK3BMAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026336-B1 | 4-pyridinylimidazol-2-ylhydrocarbyl amine, (thio)urea, carbamic acid or sulfonamide derivatives, e.g., (2-(4-(4-Chloro-3-methoxy-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-carbamic acid tert-butyl ester; Raf kinase inhibitors for the treatment of neurotraumatic diseases | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-04-11 | — | — | US | disclosed |
| EP-1232153-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-11-03 | — | — | EP | disclosed |