Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5962342 | 0.81 | MAPK14 (0.54) | MAPK14CSNK1DGSK3AGSK3B | |
| SCHEMBL5962308 | 0.80 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5962311 | 0.80 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5962428 | 0.79 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL7677062 | 0.79 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6808788 | 0.79 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5962371 | 0.75 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5769478 | 0.75 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5770650 | 0.75 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5772359 | 0.74 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026336-B1 | 4-pyridinylimidazol-2-ylhydrocarbyl amine, (thio)urea, carbamic acid or sulfonamide derivatives, e.g., (2-(4-(4-Chloro-3-methoxy-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-carbamic acid tert-butyl ester; Raf kinase inhibitors for the treatment of neurotraumatic diseases | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-04-11 | — | — | US | disclosed |
| EP-1232153-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-11-03 | — | — | EP | disclosed |