Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.74 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.55 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13229409 | 0.91 | DGAT1 (0.81) | DGAT1SOAT2SOAT1 | |
| SCHEMBL2491224 | 0.90 | DGAT1 (0.78) | DGAT1SOAT2SOAT1 | |
| SCHEMBL13229422 | 0.89 | DGAT1 (0.80) | DGAT1 | |
| SCHEMBL594953 | 0.88 | DGAT1 (0.72) | DGAT1 | |
| SCHEMBL1090552 | 0.88 | DGAT1 (0.79) | DGAT1SOAT2SOAT1 | |
| SCHEMBL595918 | 0.88 | DGAT1 (0.86) | DGAT1SOAT2SOAT1 | |
| SCHEMBL13229292 | 0.88 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL13229289 | 0.88 | DGAT1 (0.76) | DGAT1 | |
| SCHEMBL13229417 | 0.87 | DGAT1 (0.73) | DGAT1SOAT2SOAT1 | |
| SCHEMBL2447634 | 0.87 | DGAT1 (0.78) | DGAT1SOAT2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153644-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8115011-B2 | (S)-3-{5-[(1-Pyridin-2-yl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)-amino]-pyridin-2-ylamino}-pyrrolidine-1-carboxylic acid ethyl ester; obesity, type II diabetes mellitus and metabolic syndrome | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8058299-B2 | Diacylglycerol acyltransferase inhibitors | VIA PHARMACEUTICALS, INC. (US) | 2011-11-15 | — | — | US | disclosed |