Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 7/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965710 | 0.90 | HRH3 (0.44) | CCR3HTR2ACHRM1MCHR1DRD3 | |
| SCHEMBL6995086 | 0.83 | CCR3 (0.49) | CCR3HTR2ACHRM1MCHR1DRD3 | |
| SCHEMBL2966823 | 0.83 | CCR3 (0.48) | CCR3HTR2ACHRM1MCHR1DRD3 | |
| SCHEMBL5965836 | 0.82 | HRH3 (0.43) | CCR3HTR2ACHRM1MCHR1DRD3 | |
| SCHEMBL5965538 | 0.80 | DRD3 (0.40) | CCR3HTR2ADRD3DRD2PRKAA2 | |
| SCHEMBL5965774 | 0.80 | PRKAA2 (0.46) | DRD3DRD2PRKAA2HRH2HRH1 | |
| SCHEMBL5965797 | 0.77 | MEN1 (0.40) | CCR3HTR2ACHRM1MCHR1MEN1 | |
| SCHEMBL2967662 | 0.77 | CHRM1 (0.45) | CCR3HTR2ACHRM1MCHR1DRD3 | |
| SCHEMBL5965683 | 0.77 | MEN1 (0.43) | CCR3HTR2ACHRM1MCHR1MEN1 | |
| SCHEMBL5965403 | 0.76 | MCHR1 (0.42) | MCHR1DRD3DRD2HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012074-B2 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-03-14 | — | — | US | disclosed |
| US-20040023971-A1 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | US | disclosed |
| EP-1328526-A1 | 3,8-DIAZABICYCLO[3.2.1]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002032902-A1 | 3,8-DIAZABICYCLO[3.2.1]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023971-A1 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | KCNH1, KCNH2, RYR2 | CCR3 2137/4885HTR2A 1943/4885CHRM1 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.