Sugi Predict

Sugi Predict / Targets / KCNH1

KCNH1

Voltage-gated delayed rectifier potassium channel KCNH1 · O95259 · KCNH1 on Sugi Atlas →

476 patent compounds predicted against KCNH1, 311 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL12496846 SCHEMBL12496846 1.00 6/20
SCHEMBL17200044 SCHEMBL17200044 1.00 6/20
SCHEMBL17210718 SCHEMBL17210718 1.00 6/20
SCHEMBL17210694 SCHEMBL17210694 0.74 6/20
SCHEMBL12525223 SCHEMBL12525223 1.00 5/20
SCHEMBL17699479 SCHEMBL17699479 1.00 5/20
SCHEMBL17704793 SCHEMBL17704793 1.00 5/20
SCHEMBL17704794 SCHEMBL17704794 1.00 5/20
SCHEMBL17728098 SCHEMBL17728098 1.00 5/20
SCHEMBL17699493 SCHEMBL17699493 0.79 5/20
SCHEMBL17771606 SCHEMBL17771606 0.79 5/20
SCHEMBL12525338 SCHEMBL12525338 0.76 5/20
SCHEMBL16312284 SCHEMBL16312284 0.76 5/20
SCHEMBL16306344 SCHEMBL16306344 0.74 5/20
SCHEMBL16312260 SCHEMBL16312260 0.74 5/20
SCHEMBL16312285 SCHEMBL16312285 0.74 5/20
SCHEMBL17704795 SCHEMBL17704795 0.74 5/20
SCHEMBL2154190 SCHEMBL2154190 0.73 5/20
SCHEMBL16312255 SCHEMBL16312255 0.70 5/20
SCHEMBL16312250 SCHEMBL16312250 0.69 5/20

Clinical trials — most relevant to KCNH1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Predictive Factors to Effectively Terminate Paroxysmal Atrial Fibrillation by Blocking Atrial Selective Ionic Currents PHASE4COMPLETED
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery PHASE4RECRUITING
Ondansetron for the Management of Atrial Fibrillation PHASE4RECRUITING
Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients PHASE3NOT_YET_RECRUITING
Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation PHASE2/PHASE3WITHDRAWN
Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2) PHASE2/PHASE3RECRUITING
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation PHASE3COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients PHASE2COMPLETED
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
A Single Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of SYH2085 PHASE1RECRUITING
Single Ascending Dose of GAP-134 as a 24-hour IV Infusion in Healthy Japanese Males PHASE1COMPLETED
Gene Therapy for Post-Operative Atrial Fibrillation PHASE1WITHDRAWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Prospective Identification of Long QT Syndrome in Fetal Life nanCOMPLETED
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients nanUNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia nanUNKNOWN
Characteristics of Andersen-Tawil Syndrome nanCOMPLETED
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
The Use of Antiarrhythmic Drugs in Pediatrics nanUNKNOWN
Role of SNP and DIGOXIN Response in Atrial Fibrillation Patients nanCOMPLETED
Flecainide-Short Long Study (Flec-SL) nanCOMPLETED
Sodium Channel Splicing in Heart Failure Trial (SOCS-HEFT) Prospective Study nanUNKNOWN
DECAAF: Delayed-Enhancement MRI (DE-MRI) Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation nanCOMPLETED
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNH1 binder may also engage these)

ProteinNameSimilarity
Q60603 — 1.000 Q60603 →
Q63472 — 1.000 Q63472 →
Q8NCM2 — 1.000 Q8NCM2 →
O18965 — 1.000 O18965 →
Q920E3 — 1.000 Q920E3 →
Q9EPI9 — 1.000 Q9EPI9 →
Q02280 — 0.999 Q02280 →
Q90805 — 0.992 Q90805 →
Q38849 — 0.992 Q38849 →
Q16281 — 0.992 Q16281 →
Q38998 — 0.992 Q38998 →
Q9TUI4 — 0.991 Q9TUI4 →
HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 0.991 landscape →
Q9ER47 — 0.990 Q9ER47 →
Q6K3T2 — 0.990 Q6K3T2 →
O54853 — 0.990 O54853 →
O97531 — 0.990 O97531 →
P55934 — 0.990 P55934 →
Q16280 — 0.990 Q16280 →
Q62398 — 0.989 Q62398 →
O54852 — 0.989 O54852 →
Q96L42 — 0.989 Q96L42 →
Q8MJD7 — 0.989 Q8MJD7 →
Q9NS40 — 0.989 Q9NS40 →
Q29441 — 0.989 Q29441 →
Q9ER33 — 0.988 Q9ER33 →
Q00194 — 0.988 Q00194 →
P59111 — 0.988 P59111 →
Q9MZS1 — 0.988 Q9MZS1 →
Q9QWS8 — 0.987 Q9QWS8 →