Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 16/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | FPR3 | P25089 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5968634 | 1.00 | ADRB2 (0.68) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968865 | 0.95 | ADRB2 (0.61) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968861 | 0.95 | ADRB2 (0.61) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968883 | 0.95 | ADRB2 (0.70) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968882 | 0.95 | ADRB2 (0.70) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5969116 | 0.93 | ADRB2 (0.59) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5969113 | 0.93 | ADRB2 (0.59) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968667 | 0.91 | ADRB2 (0.65) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968672 | 0.91 | ADRB2 (0.65) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 | |
| SCHEMBL5968881 | 0.90 | ADRB2 (0.57) | ADRB2ADRB1CHRM3CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727789-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | Pfizer Limited (GB) | 2006-12-06 | — | — | EP | claimed |
| WO-2005090287-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LIMITED (GB) | 2005-09-29 | — | — | WO | claimed |
| EP-1727789-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | Pfizer Limited (GB) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005090287-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |