Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6901253 | 1.00 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL8144221 | 1.00 | — | — | |
| Bicarbonate SCHEMBL6902970 | 1.00 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL6704233 | 1.00 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL1318470 | 1.00 | — | — | |
| Bicarbonate SCHEMBL28206706 | 1.00 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL5346447 | 1.00 | — | — | |
| Bicarbonate SCHEMBL9476612 | 0.94 | — | — | |
| Bicarbonate SCHEMBL242847 | 0.94 | — | — | |
| Bicarbonate SCHEMBL9299559 | 0.94 | CA1 (0.62) | CA1CA2CA9FFAR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4387955-A1 | SYNTHESIS OF BRIVARACETAM | OPTIMUS DRUGS PRIVATE LIMITED (IN) | 2024-06-26 | — | — | EP | claimed |
| CN-117043141-A | 7-nitro-8-hydroxyquinoline derivative, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-11-10 | — | — | CN | claimed |
| WO-2023076589-A1 | PRETREATMENT OF LIGNOCELLULOSE USING TWO STAGE ALKALI AND MECHANICAL REFINING PROCESSES | ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) | 2023-05-04 | — | — | WO | claimed |
| WO-2023021363-A1 | SYNTHESIS OF BRIVARACETAM | OPTIMUS DRUGS PRIVATE LIMITED (IN) | 2023-02-23 | — | — | WO | claimed |
| WO-2022253152-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏亚虹医药科技股份有限公司 | 2022-12-08 | — | — | WO | claimed |
| CN-115368412-A | Method for preparing minodronic acid | 扬子江药业集团北京海燕药业有限公司 | 2022-11-22 | — | — | CN | claimed |
| CN-214780790-U | Waste incineration fly ash recycling combination device | 上海东硕环保科技股份有限公司 | 2021-11-19 | — | — | CN | claimed |
| CN-112551557-A | Waste incineration fly ash recycling combination device and use method thereof | 上海东硕环保科技股份有限公司 | 2021-03-26 | — | — | CN | claimed |
| CN-111974386-A | Carbonyl sulfide hydrolysis catalyst and preparation method thereof | 济南环陶环保工程有限公司 | 2020-11-24 | — | — | CN | claimed |
| CN-109621103-A | Method for generating the suction apparatus of aerosol and generating aerosol | 帕瑞-高效雾化吸入治疗专家 | 2019-04-16 | — | — | CN | claimed |
| EP-1597231-A1 | DERIVATIVES OF AZASUGARS AS ANTICANCER AGENTS | RANBAXY LABORATORIES, LTD. (IN) | 2005-11-23 | — | — | EP | claimed |
| WO-2004074251-A1 | DERIVATIVES OF AZASUGARS AS ANTICANCER AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2004-09-02 | — | — | WO | claimed |
| US-20030125553-A1 | Process for the preparation of new antidiabetic agents | DR. REDDY'S LABORATORIES LIMITED | 2003-07-03 | — | — | US | claimed |
| EP-1086140-A1 | MODIFIED GELLAN GUM COMPOSITION PROCESS FOR PREPARATION OF SAME AND USE THEREOF | Monsanto p.l.c. (GB) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064468-A1 | MODIFIED GELLAN GUM COMPOSITION PROCESS FOR PREPARATION OF SAME AND USE THEREOF | MONSANTO P.L.C. (GB) | 1999-12-16 | — | — | WO | claimed |
| US-5685898-A | MIXTURE OF A PALLADIUM SALT, A COMPLEXING AGENT, A WATER SOLUBLE POLYMER, AN ALKALINE COMPOUND AND A SOLVENT | BLUE CHIPS HOLDING (LU) | 1997-11-11 | — | — | US | claimed |
| US-5124237-A | Production of photopolymerized relief printing plates having a non-tacky surface | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-23 | — | — | US | claimed |
| US-5118345-A | High strength; contains fired carbon black, graphite, water, alkali metal phosphates, borates and carbonates | J.S. STAEDTLER GMBH & CO. (DE) | 1992-06-02 | — | — | US | claimed |
| US-4883573-A | ULTRAFILTRATION, RECYCLING | BASF AKTIENGESELLSCHAFT (DE) | 1989-11-28 | — | — | US | claimed |
| US-4340253-A | Preflush-lixiviant process for solution mining of uranium ore beds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) | 1982-07-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125553-A1 | Process for the preparation of new antidiabetic agents | GLP1R, GPR119, SLC5A1 | CA1 3473/4885CA2 2615/4885CA9 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.