Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.52 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5971137 | 0.88 | ATM (0.51) | ADORA2BABL1SRCMEN1LMNA | |
| SCHEMBL5970239 | 0.81 | ADORA2B (0.51) | ADORA2BXDHADORA2AADORA1LMNA | |
| SCHEMBL5970162 | 0.81 | ADORA2B (0.49) | ADORA2BMAPK14MEN1MAPTKMT2A | |
| SCHEMBL5970230 | 0.81 | ADORA2B (0.48) | ADORA2BXDHPTGS2MAPTHPSE | |
| SCHEMBL5970460 | 0.80 | NPC1 (0.48) | ADORA2BIDH1MAPK14MEN1MAPT | |
| SCHEMBL5971321 | 0.80 | ADORA2B (0.48) | ADORA2BXDHPTGS2MAPK14MEN1 | |
| SCHEMBL5970231 | 0.80 | ADORA2B (0.56) | ADORA2BXDHMAP4K4ADORA2AADORA1 | |
| SCHEMBL5970527 | 0.79 | ADORA2B (0.57) | ADORA2BXDHADORA2AMEN1MAPT | |
| SCHEMBL5970324 | 0.79 | ATM (0.47) | ADORA2BIDH1MEN1LMNAMAPT | |
| SCHEMBL5970374 | 0.78 | ADORA2B (0.48) | ADORA2BXDHMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658291-A2 | SUBSTITUTED 8-HETEROARYL XANTHINES | Adenosine Therapeutics, LLC (US) | 2006-05-24 | — | — | EP | claimed |
| WO-2005021548-A2 | SUBSTITUTED 8-HETEROARYL XANTHINES | ADENOSINE THERAPEUTICS, LLC (US) | 2005-03-10 | — | — | WO | claimed |