Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 19/20 | 0.68 |
| ▸ | GRIN2D | O15399 | 18/20 | 0.68 |
| ▸ | GRIN3B | O60391 | 18/20 | 0.68 |
| ▸ | GRIN2A | Q12879 | 18/20 | 0.68 |
| ▸ | GRIN2B | Q13224 | 18/20 | 0.68 |
| ▸ | GRIN2C | Q14957 | 18/20 | 0.68 |
| ▸ | GRIN3A | Q8TCU5 | 18/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639494 | 0.81 | GRIN2D (1.00) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7784329 | 0.78 | GRIN2D (1.00) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL4704849 | 0.78 | GRIN1 (0.66) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL463620 | 0.78 | GRIN1 (0.66) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL5973354 | 0.77 | GRIN1 (0.67) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL5973665 | 0.75 | GRIN1 (0.64) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8872169 | 0.73 | GRIN2D (0.85) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL4707291 | 0.73 | GRIN1 (0.59) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Phosphonic Acid SCHEMBL27504235 | 0.72 | GRIN1 (0.60) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7345843 | 0.72 | GRIN2D (1.00) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934326-B1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-6117873-A | CAN BE USED FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS WHICH RESPOND TO BLOCKAGE OF EXCITATORY AMINO ACID RECEPTORS | NOVARTIS AG (CH) | 2000-09-12 | — | — | US | disclosed |
| EP-0934326-A1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | Novartis AG (CH) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017672-A1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |