Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 15/20 | 0.67 |
| ▸ | GRIN2D | O15399 | 14/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 14/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 14/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 14/20 | 0.67 |
| ▸ | GRIN3A | Q8TCU5 | 14/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19779947 | 0.85 | GRIN1 (0.48) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7784329 | 0.80 | GRIN2D (1.00) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL31285296 | 0.79 | GRIN1 (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL4706160 | 0.79 | GRIN1 (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL2639882 | 0.79 | GRIN1 (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL2640204 | 0.79 | GRIN1 (0.66) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL12970315 | 0.79 | GRIN2D (0.47) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL5974273 | 0.78 | GRIN1 (0.60) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL5973771 | 0.77 | GRIN1 (0.68) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL5973665 | 0.77 | GRIN1 (0.64) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934326-B1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-6117873-A | CAN BE USED FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS WHICH RESPOND TO BLOCKAGE OF EXCITATORY AMINO ACID RECEPTORS | NOVARTIS AG (CH) | 2000-09-12 | — | — | US | disclosed |
| EP-0934326-A1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | Novartis AG (CH) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017672-A1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |