Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.73 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.73 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.73 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.73 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.73 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.73 |
| ▸ | PPARA | Q07869 | 17/20 | 0.68 |
| ▸ | PPARD | Q03181 | 7/20 | 0.66 |
| ▸ | PPARG | P37231 | 6/20 | 0.66 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13460899 | 0.89 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6383495 | 0.87 | PSEN1 (0.80) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6380278 | 0.87 | PSEN1 (0.74) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5974498 | 0.84 | PPARA (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6376145 | 0.84 | PSEN1 (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6376141 | 0.84 | PSEN1 (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6501430 | 0.83 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6501421 | 0.83 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6501426 | 0.83 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5974875 | 0.83 | PPARA (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1219595-B1 | O-ANISAMIDE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2006-01-18 | — | — | EP | disclosed |
| EP-1184366-B1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA(PPAR) | KYORIN SEIYAKU KK (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6706763-B1 | AGONISTIC DRUG ON HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-6506797-B1 | Activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor alpha alpha ), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2003-01-14 | — | — | US | disclosed |
| EP-1219595-A1 | O-ANISAMIDE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-1184366-A1 | SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES AS AGONISTS TO HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA(PPAR) | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |