Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 12/20 | 0.60 |
| ▸ | GRIN2D | O15399 | 11/20 | 0.60 |
| ▸ | GRIN3B | O60391 | 11/20 | 0.60 |
| ▸ | GRIN2A | Q12879 | 11/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.60 |
| ▸ | GRIN2C | Q14957 | 11/20 | 0.60 |
| ▸ | GRIN3A | Q8TCU5 | 11/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23269912 | 0.85 | MAPT (0.44) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7779818 | 0.83 | GRIN1 (0.46) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL10285831 | 0.83 | GRIN1 (0.47) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL2639502 | 0.81 | GRIN1 (0.45) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8609931 | 0.81 | GRIN1 (0.45) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL2639004 | 0.81 | GRIN1 (0.59) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL21642466 | 0.81 | GRIN1 (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL5973354 | 0.78 | GRIN1 (0.67) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7787986 | 0.77 | GRIN1 (0.51) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8873491 | 0.77 | GRIN1 (0.41) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011112731-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |
| EP-0647137-B1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | UNIV CALIFORNIA (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-0934326-B1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-6117873-A | CAN BE USED FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS WHICH RESPOND TO BLOCKAGE OF EXCITATORY AMINO ACID RECEPTORS | NOVARTIS AG (CH) | 2000-09-12 | — | — | US | disclosed |
| EP-0934326-A1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | Novartis AG (CH) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017672-A1 | SUBSTITUTED AMINOALKANE PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |