Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 18/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.75 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006440 | 1.00 | OPRD1 (0.75) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5175825 | 0.92 | OPRD1 (0.76) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5173818 | 0.92 | OPRD1 (0.76) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL14343287 | 0.92 | OPRD1 (0.72) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5172446 | 0.92 | OPRD1 (0.74) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5173044 | 0.92 | OPRD1 (0.74) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5175014 | 0.92 | OPRD1 (0.74) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5618411 | 0.91 | OPRD1 (0.71) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5618406 | 0.91 | OPRD1 (0.71) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5174644 | 0.91 | OPRD1 (0.73) | OPRD1OPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706393-A1 | DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | claimed |
| WO-2005066148-A1 | DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | claimed |