Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 9/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944173 | 0.93 | PTGER4 (0.51) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL5990886 | 0.91 | PTGER4 (0.53) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL5982721 | 0.89 | PTGER4 (0.51) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL4940816 | 0.84 | PTGER4 (0.53) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL4937190 | 0.82 | PTGER4 (0.51) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL4937202 | 0.81 | PTGER4 (0.54) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL13992256 | 0.81 | PTGER4 (0.59) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL5982971 | 0.81 | CYP3A4 (0.43) | PTGER4PTGER2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4937196 | 0.80 | PTGER4 (0.54) | PTGER4PTGER2TBXA2RCYP3A4CYP1A2 | |
| SCHEMBL5983008 | 0.79 | PTGER4 (0.51) | PTGER4PTGER2TBXA2ROPRM1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654219-A2 | HYDRAZIDE DERIVATIVES AS PROSTAGLANDIN RECEPTORS MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005012232-A2 | HYDRAZIDE DERIVATIVES AS PROSTAGLANDIN RECEPTORS MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2005-02-10 | — | — | WO | disclosed |