Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1737176 | 1.00 | ADORA2A (0.51) | ADORA2AADORA2BADORA3LMNANT5E | |
| SCHEMBL5962974 | 0.93 | ADORA2A (0.51) | ADORA2AADORA2BADORA3LMNANT5E | |
| SCHEMBL5983866 | 0.93 | ADORA2A (0.51) | ADORA2AADORA2BADORA3LMNANT5E | |
| SCHEMBL5983004 | 0.89 | ADORA1 (0.60) | ADORA2AADORA2BADORA3HIF1AADORA1 | |
| SCHEMBL4556302 | 0.89 | ADORA1 (0.60) | ADORA2AADORA2BADORA3HIF1AADORA1 | |
| SCHEMBL5982891 | 0.86 | ADORA1 (0.61) | ADORA2AADORA2BADORA3HIF1AADORA1 | |
| SCHEMBL5982880 | 0.86 | ADORA1 (0.61) | ADORA2AADORA2BADORA3HIF1AADORA1 | |
| SCHEMBL1738169 | 0.85 | HPGD (0.49) | ADORA2AADORA2BNT5E | |
| SCHEMBL5962965 | 0.85 | HPGD (0.49) | ADORA2AADORA2BNT5E | |
| SCHEMBL5963222 | 0.85 | ADORA2A (0.70) | ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037646-B1 | Amine-derivatized nucleosides and oligonucleosides | ISIS PHARMACEUTICALS, INC. (US) | 2006-05-02 | — | — | US | disclosed |
| EP-0728139-B1 | AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0728139-A1 | AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995006659-A1 | AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-03-09 | — | — | WO | disclosed |