SCHEMBL4556302

SCHEMBL4556302

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OCCCCn1ccnc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 2/20 0.60
ADORA3 P0DMS8 4/20 0.59
DPP4 P27487 1/20 0.59
MEN1 O00255 1/20 0.59
SLC28A1 O00337 1/20 0.59
MAP3K7 O43318 1/20 0.59
SLC28A2 O43868 1/20 0.59
GAPDH P04406 1/20 0.59
MAPK1 P28482 1/20 0.59
ADORA2A P29274 1/20 0.59
ADORA2B P29275 1/20 0.59
STAT6 P42226 1/20 0.59
PI4KA P42356 1/20 0.59
KMT2A Q03164 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
PI4K2B Q8TCG2 1/20 0.59
DOT1L Q8TEK3 1/20 0.59
SLC29A1 Q99808 1/20 0.59
PI4K2A Q9BTU6 1/20 0.59
SLC28A3 Q9HAS3 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5983004 1.00 ADORA1 (0.60) ADORA1ADORA3DPP4MEN1SLC28A1
SCHEMBL5982880 0.97 ADORA1 (0.61) ADORA1ADORA3DPP4MEN1SLC28A1
SCHEMBL5982891 0.97 ADORA1 (0.61) ADORA1ADORA3DPP4MEN1SLC28A1
SCHEMBL5983285 0.93 ADORA3 (0.59) ADORA1ADORA3DPP4MEN1SLC28A1
SCHEMBL5983294 0.93 ADORA3 (0.59) ADORA1ADORA3DPP4MEN1SLC28A1
SCHEMBL1737176 0.89 ADORA2A (0.51) ADORA1ADORA3ADORA2AADORA2BHIF1A
SCHEMBL5982371 0.89 ADORA2A (0.51) ADORA1ADORA3ADORA2AADORA2BHIF1A
SCHEMBL5981506 0.85 GSK3A (0.56)
SCHEMBL6261501 0.85 ADORA2A (0.67) ADORA1ADORA3DPP4MEN1SLC28A1
SCHEMBL6849225 0.85 ADORA3 (0.67) ADORA1ADORA3DPP4MEN1SLC28A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090198047-A1 2'-Modified Oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 2009-08-06 US disclosed
US-20080032945-A1 2'-MODIFIED OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. (US) 2008-02-07 US disclosed
US-7138517-B2 Sugar modified oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 2006-11-21 US disclosed
US-7037646-B1 Amine-derivatized nucleosides and oligonucleosides ISIS PHARMACEUTICALS, INC. (US) 2006-05-02 US disclosed
US-20030187240-A1 2' -modified oligonucleotides ISIS PHARMACEUTICALS, INC. 2003-10-02 US disclosed
EP-0728139-B1 AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES ISIS PHARMACEUTICALS INC (US) 2003-08-13 EP disclosed
US-6531584-B1 Nuclease resistant oligonucleotide analogs; DNA or RNA modulation; diagnosis, thearpy of viral diseases ISIS PHARMACEUTICALS, INC. 2003-03-11 US disclosed
US-6399754-B1 CONTAINING SULFOPHOSPHATE GROUP ISIS PHARMACEUTICALS, INC. 2002-06-04 US disclosed
US-6005087-A NUCLEASE RESISTANT OLIGONUCLEOTIDES WHICH ARE USEFUL AS THERAPEUTICS, DIAGNOSTICS, AND RESEARCH REAGENTS FOR VARIOUS VIRAL DISEASES ISIS PHARMACEUTICALS, INC. (US) 1999-12-21 US disclosed
EP-0728139-A1 AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES ISIS PHARMACEUTICALS, INC. (US) 1996-08-28 EP disclosed
WO-1995006659-A1 AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES ISIS PHARMACEUTICALS, INC. (US) 1995-03-09 WO disclosed