Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332619 | 0.94 | PTGDR2 (0.45) | PTGDR2PSMD14APAF1POLBGRK2 | |
| SCHEMBL1331606 | 0.82 | PTGDR2 (0.66) | PTGDR2 | |
| SCHEMBL1333647 | 0.78 | ALDH1A1 (0.53) | PTGDR2LMNAALDH1A1HTT | |
| SCHEMBL1333490 | 0.78 | PTGDR2 (0.48) | PTGDR2LMNAPKMMCOLN3ALDH1A1 | |
| SCHEMBL1332102 | 0.76 | CPT1A (0.54) | LMNAMAPK1ALDH1A1HTT | |
| SCHEMBL1333542 | 0.76 | HSD17B2 (0.49) | POLBLMNAMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31345532 | 0.73 | ALDH1A1 (0.56) | LMNAMCOLN3MAPK1ALDH1A1HTT | |
| SCHEMBL2397755 | 0.73 | PTGDR2 (0.46) | PTGDR2LMNAMAPK1ALDH1A1 | |
| SCHEMBL1333702 | 0.73 | SLC6A2 (0.51) | LMNAALDH1A1 | |
| SCHEMBL3927508 | 0.72 | MRGPRX4 (0.44) | LMNAMAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660431-A2 | PHENOXYACETIC ACID DERIVATIVES | Astrazeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005018529-A2 | PHENOXIACETIC ACID DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |