Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490912 | 0.87 | MEN1 (0.52) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL8943896 | 0.84 | ATM (0.45) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL19194076 | 0.83 | MAPK1 (0.38) | KDM1AALDH1A1MAPK1LMNACYP1A2 | |
| SCHEMBL8944199 | 0.83 | GAA (0.45) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL5051039 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL10725249 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL10516376 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL8944210 | 0.82 | GAA (0.47) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL8944077 | 0.82 | GAA (0.47) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL8944026 | 0.82 | GAA (0.47) | ALDH1A1MAPK1LMNACYP1A2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME LLC | 2018-06-21 | — | — | US | disclosed |
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME LLC | 2018-06-21 | — | — | US | disclosed |
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME LLC | 2018-06-21 | — | — | US | disclosed |
| US-20170216295-A1 | CCR9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-08-03 | — | — | US | disclosed |
| WO-2017000277-A1 | SUBSTITUTED TRIAZOLO BICYCLICCOMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-01-05 | — | — | WO | disclosed |
| WO-2017003894-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-01-05 | — | — | WO | disclosed |
| US-8889340-B2 | Method for making a lithographic printing plate | AGFA GRAPHICS, N.V. (BE) | 2014-11-18 | — | — | US | disclosed |
| US-8889340-B2 | Method for making a lithographic printing plate | AGFA GRAPHICS, N.V. (BE) | 2014-11-18 | — | — | US | disclosed |
| US-5587281-A | TABULAR GRAINS | FUJI PHOTO FILM CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0443453-B1 | Silver halide photographic emulsion and photographic light-sensitive material using the same | FUJI PHOTO FILM CO LTD (JP) | 1996-08-21 | — | — | EP | disclosed |
| EP-0697618-A1 | Method for producting silver halide grain and silver halide emulsion using the grain | FUJI PHOTO FILM CO., LTD. (JP) | 1996-02-21 | — | — | EP | disclosed |
| US-5480716-A | MULTILAYER ELEMENT WITH SUPPORT AND MAGNETIC LAYER WITH FERROMAGNETIC METALS | FUJI PHOTO FILM CO., LTD. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |
| US-5085981-A | Gelatin-reactive acrylic binder and fine particles of silca; wear resistance; retouchability | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1992-02-04 | — | — | US | disclosed |
| EP-0443453-A1 | Silver halide photographic emulsion and photographic light-sensitive material using the same | FUJI PHOTO FILM CO., LTD. (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-5015567-A | Sensitization In The Presence Of An Organic Thioether Or A Tetra-substituted Thiourea And A Triazolopyrimidine Stabilizer | FUJI PHOTO FILM CO., LTD. (JP) | 1991-05-14 | — | — | US | disclosed |
| EP-0220458-A1 | Herbicidal agents on the basis of triazolo pyrimidines | BAYER AG (DE) | 1987-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | PDE2A, PDE3A, PDE4D | KDM1A 2373/4885ALDH1A1 1376/4885MAPK1 1272/4885 |
| US-20170216295-A1 | CCR9 ANTAGONIST COMPOUNDS | CCR9, CCR1, CCR10 | KDM1A 2641/4885ALDH1A1 1264/4885MAPK1 741/4885 |
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | PDE2A, PDE3A, PDE4D | KDM1A 2373/4885ALDH1A1 1376/4885MAPK1 1272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.