Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 12/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5986046 | 1.00 | BDKRB1 (0.51) | BDKRB1ALDH1A1POLBMAPTMMP2 | |
| SCHEMBL4516397 | 0.90 | BDKRB1 (0.52) | BDKRB1ALDH1A1POLBMAPTMMP2 | |
| SCHEMBL4523939 | 0.86 | ALDH1A1 (0.67) | BDKRB1ALDH1A1POLBMAPTMMP2 | |
| SCHEMBL4519076 | 0.86 | ALDH1A1 (0.67) | BDKRB1ALDH1A1POLBMAPTMMP2 | |
| SCHEMBL14307677 | 0.83 | BDKRB1 (0.40) | BDKRB1ALDH1A1MAPT | |
| SCHEMBL5982557 | 0.79 | ALDH1A1 (0.74) | BDKRB1ALDH1A1POLBMAPT | |
| SCHEMBL5982477 | 0.79 | ALDH1A1 (0.74) | BDKRB1ALDH1A1POLBMAPT | |
| SCHEMBL5984080 | 0.79 | ALDH1A1 (0.74) | BDKRB1ALDH1A1POLBMAPT | |
| SCHEMBL14318666 | 0.78 | ALDH1A1 (0.49) | BDKRB1ALDH1A1POLBMAPTMMP2 | |
| SCHEMBL5503691 | 0.73 | BDKRB1 (0.66) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | disclosed |