Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5987232 | 0.94 | PTGS2 (0.35) | PTPN1TRPM8PTGS2PTPN2 | |
| SCHEMBL5988072 | 0.92 | PTPN5 (0.37) | PTPN1TRPM8PTGS2PTPN2NR1H2 | |
| SCHEMBL5987121 | 0.88 | PTPN1 (0.40) | PTPN1TRPM8PTGS2PTPN2 | |
| SCHEMBL5503559 | 0.85 | PTPN1 (0.41) | PTPN1PTGS2PTPN2NR1H2NR1H3 | |
| SCHEMBL5502408 | 0.84 | PTPN1 (0.42) | PTPN1PTGS2PTPN2 | |
| SCHEMBL5508476 | 0.81 | LTB4R2 (0.40) | PTPN1 | |
| SCHEMBL5987489 | 0.79 | PTPN1 (0.47) | PTPN1PTGS2PTPN2 | |
| SCHEMBL5503895 | 0.78 | PTPN1 (0.37) | PTPN1PTPN2 | |
| SCHEMBL5988142 | 0.78 | PTPN1 (0.39) | PTPN1PTGS2PTPN2 | |
| SCHEMBL5500025 | 0.77 | PTPN1 (0.40) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060135483-A1 | Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135483-A1 | Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases | PTPRO, PTPRG, PTPN1 | PTPN1 3/4885TRPM8 4558/4885PTGS2 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.