Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.72 |
| ▸ | STS | P08842 | 6/20 | 0.63 |
| ▸ | SHBG | P04278 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588779 | 0.85 | HSD11B1 (0.65) | HSD11B1STSSHBGLMNAMAPT | |
| SCHEMBL7830892 | 0.84 | HSD11B1 (0.69) | HSD11B1STSSHBGLMNAMAPT | |
| SCHEMBL1657830 | 0.84 | HSD11B1 (0.69) | HSD11B1STSSHBGLMNAMAPT | |
| SCHEMBL13268578 | 0.83 | HSD11B1 (1.00) | HSD11B1STSSHBGLMNAMAPT | |
| SCHEMBL18798683 | 0.83 | HSD11B1 (0.78) | HSD11B1STSLMNAMAPTESR1 | |
| SCHEMBL806082 | 0.83 | HSD11B1 (0.78) | HSD11B1STSLMNAMAPTESR1 | |
| SCHEMBL11672788 | 0.83 | HSD11B1 (0.78) | HSD11B1STSSHBGLMNAMAPT | |
| SCHEMBL3649589 | 0.83 | HSD11B1 (0.78) | HSD11B1STSLMNAMAPTESR1 | |
| SCHEMBL7830895 | 0.82 | HSD11B1 (0.69) | HSD11B1STSSHBGLMNAMAPT | |
| SCHEMBL9644320 | 0.82 | HSD11B1 (0.66) | HSD11B1STSSHBGLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716166-A2 | 17-METHYLENE- OR 17-SPIRO-CYCLOPROPANE 7-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE DERIVATIVES WITH ANTI-ESTROGENIC ACTIVITY | Innoventus Project AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005077968-A2 | 17-METHYLENE-OR 17 - SPIRO - CYCLOPROPANE 7 - SUBSTITUTED ESTRA - 1, 3, 5 (10) - TRIENE DERIVATIVES WITH ANTI - ESTROGENIC ACTIVITY | INNOVENTUS PROJECT AB (SE) | 2005-08-25 | — | — | WO | disclosed |
| EP-0920441-A1 | 7ALPHA-(EPSILON-AMINOALKYL)-ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7ALPHA-(EPSILON-AMINOALKYL)-ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENT | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007740-A1 | 7α-(κ-AMINOALKYL)ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7α-(κ-AMINOALKYL)ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-02-26 | — | — | WO | disclosed |
| EP-0471612-A2 | New steroids having an amide substituted group in the 11-beta position, their preparation, their use as medicines and pharmaceutical composition thereof | ROUSSEL UCLAF (FR) | 1992-02-19 | — | — | EP | disclosed |