Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 4/20 | 0.33 |
| ▸ | GABRD | O14764 | 4/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9151775 | 0.85 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL1565106 | 0.81 | — | — | |
| Acetic Acid SCHEMBL4292108 | 0.81 | FFAR3 (0.54) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL10589745 | 0.81 | — | — | |
| Acetic Acid SCHEMBL6425236 | 0.79 | FFAR3 (0.50) | FFAR3LCKFYNTP53SLC7A5 | |
| Propionic Acid SCHEMBL23466906 | 0.78 | FFAR3 (0.59) | FFAR3TP53SLC7A5LMNAGABRP | |
| Acetic Acid SCHEMBL44094 | 0.77 | — | — | |
| Acetic Acid SCHEMBL28157960 | 0.77 | — | — | |
| Acetic Acid SCHEMBL670655 | 0.77 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL27717337 | 0.77 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060110379-A1 | Linkage of agents using microparticles | PERICOR SCIENCE, INC. (US) | 2006-05-25 | — | — | US | disclosed |
| US-20060104966-A1 | Transglutaminase linkage of agents to tissue | PERICOR SCIENCE, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-6958148-B1 | Linkage of agents to body tissue using microparticles and transglutaminase | PERICOR SCIENCE, INC. (US) | 2005-10-25 | — | — | US | disclosed |
| WO-2005092273-A2 | METHOD OF COMPATIBILIZING CATIONIC MATERIALS WITH ANIONIC POLYMERS | NOVEON IP HOLDINGS CORP. (US) | 2005-10-06 | — | — | WO | disclosed |
| CN-1678282-A | Compositions of anionic polymeric rheology modifiers and cationic materials | NOVEON IP HOLDINGS CORP (US) | 2005-10-05 | — | — | CN | disclosed |
| US-6919076-B1 | Conjugates of agents and transglutaminase substrate linking molecules | PERICOR SCIENCE, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1534221-A1 | COMPOSITIONS OF ANIONIC POLYMERIC RHEOLOGY MODIFIERS AND CATIONIC MATERIALS | Noveon IP Holdings Corp. (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20040170587-A1 | Method of compatibilizing cationic materials with anionic polymers | LUBRIZOL ADVANCED MATERIALS, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2004026271-A1 | COMPOSITIONS OF ANIONIC POLYMERIC RHEOLOGY MODIFIERS AND CATIONIC MATERIALS | NOVEON IP HOLDINGS CORP. (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040052748-A1 | Compositions of anionic polymeric rheology modifiers and cationic materials | LUBRIZOL ADVANCED MATERIALS, INC. | 2004-03-18 | — | — | US | disclosed |
| EP-1303260-A2 | LINKAGE OF AGENTS USING MICROPARTICLES | Pericor Science, Inc. (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-1203141-A1 | LINKAGE OF AGENTS TO TISSUE | Pericor Science, Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1202706-A1 | LYSINE OXIDASE LINKAGE OF AGENTS TO TISSUE | Pericor Science, Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002007707-A2 | LINKAGE OF AGENTS USING MICROPARTICLES | PERICOR SCIENCE, INC. (US) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001007009-A1 | LYSINE OXIDASE LINKAGE OF AGENTS TO TISSUE | PERICOR SCIENCE, INC. (US) | 2001-02-01 | — | — | WO | disclosed |
| WO-2001006829-A2 | LINKAGE OF AGENTS TO TISSUE | PERICOR SCIENCE, INC. (US) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040170587-A1 | Method of compatibilizing cationic materials with anionic polymers | PARN, PARG, PICALM | FFAR3 4365/4885LCK 4266/4885FYN 3497/4885 |
| US-20040052748-A1 | Compositions of anionic polymeric rheology modifiers and cationic materials | PBRM1, PARG, PARN | FFAR3 3015/4885LCK 2412/4885FYN 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.