Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.64 |
| ▸ | KDR | P35968 | 7/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | FLT4 | P35916 | 3/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.64 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.64 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.64 |
| ▸ | CSF1R | P07333 | 2/20 | 0.64 |
| ▸ | FLT1 | P17948 | 2/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17480291 | 0.82 | RET (0.71) | RETKDRALKFLT3FGFR1 | |
| SCHEMBL5990284 | 0.81 | RET (0.61) | RETKDRALKFLT3FGFR1 | |
| SCHEMBL5989863 | 0.80 | KDR (0.49) | RETKDRALKFLT3FGFR1 | |
| SCHEMBL6390606 | 0.80 | RET (0.64) | RETKDRALKFLT3FGFR1 | |
| SCHEMBL12694942 | 0.80 | RET (0.64) | RETKDRALKFLT3FGFR1 | |
| SCHEMBL6390610 | 0.80 | RET (0.64) | RETKDRALKFLT3FGFR1 | |
| Semaxanib SCHEMBL19572 | 0.79 | RET (1.00) | RETKDRALKFLT3FGFR1 | |
| Semaxanib SCHEMBL29351025 | 0.79 | RET (1.00) | RETKDRALKFLT3FGFR1 | |
| Semaxanib SCHEMBL29373311 | 0.79 | RET (1.00) | RETKDRALKFLT3FGFR1 | |
| Semaxanib SCHEMBL28266617 | 0.79 | RET (1.00) | RETKDRALKFLT3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |