Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988182 | 0.81 | PDPK1 (0.41) | KDRFGFR1SRCRETPDGFRB | |
| SCHEMBL5988023 | 0.80 | RET (0.64) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL6001450 | 0.79 | KDR (0.63) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL6001449 | 0.79 | KDR (0.63) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL5990287 | 0.78 | PDGFRB (0.72) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL5989465 | 0.76 | PDGFRB (0.55) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL15711681 | 0.74 | NTRK1 (0.49) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL5989066 | 0.74 | KDR (0.45) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL5988064 | 0.74 | KDR (0.49) | KDRFGFR1SRCNTRK1NTRK3 | |
| SCHEMBL5988039 | 0.73 | KDR (0.51) | KDRFGFR1SRCNTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | disclosed |