Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989066 | 0.90 | KDR (0.45) | KDRRETFLT3ALKABL1 | |
| SCHEMBL6001449 | 0.81 | KDR (0.63) | KDRRETFLT3ALKABL1 | |
| SCHEMBL6001450 | 0.81 | KDR (0.63) | KDRRETFLT3ALKABL1 | |
| SCHEMBL5989001 | 0.80 | RET (0.69) | KDRRETFLT3ALKABL1 | |
| SCHEMBL5990283 | 0.78 | PDGFRB (0.75) | KDRPDGFRBFGFR1SRCZAP70 | |
| SCHEMBL5988803 | 0.76 | KDR (0.58) | KDRRETFLT3ALKABL1 | |
| SCHEMBL5989863 | 0.74 | KDR (0.49) | KDRRETFLT3ALKABL1 | |
| SCHEMBL5988173 | 0.73 | RET (0.43) | KDRRETFLT3ALKABL1 | |
| SCHEMBL5990301 | 0.73 | RET (0.43) | KDRRETFLT3ALKABL1 | |
| SCHEMBL5991041 | 0.73 | PDE3B (0.45) | KDRRETFLT3ALKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | disclosed |