Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 4/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
| ▸ | FLT3 | P36888 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988662 | 0.84 | MAPT (0.35) | KDRPDGFRBMAPTNPC1KMT2A | |
| SCHEMBL5988057 | 0.81 | KDR (0.43) | KDRPDGFRBMAPTNPC1KMT2A | |
| SCHEMBL5989409 | 0.80 | PDGFRB (0.47) | KDRPDGFRBALKPDPK1FLT1 | |
| SCHEMBL5989881 | 0.79 | ALK (0.37) | KDRPDGFRBMAPTNPC1KMT2A | |
| SCHEMBL5989630 | 0.78 | RET (0.54) | KDRPDGFRBMAPTNPC1KMT2A | |
| SCHEMBL6388209 | 0.78 | MAPT (0.51) | KDRPDGFRBMAPTNPC1KMT2A | |
| SCHEMBL6388211 | 0.78 | MAPT (0.51) | KDRPDGFRBMAPTNPC1KMT2A | |
| SCHEMBL5990852 | 0.76 | PDE3B (0.42) | KDRPDGFRBALKPDPK1RET | |
| SCHEMBL5989160 | 0.76 | EGFR (0.50) | KDRPDGFRBALKPDPK1FLT1 | |
| SCHEMBL5991171 | 0.76 | GSK3B (0.38) | KDRPDGFRBMAPTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |