Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988025 | 0.83 | PDGFRB (0.43) | PDE3BPDE3AKDRALKPDGFRB | |
| SCHEMBL5989523 | 0.81 | RET (0.51) | PDE3BPDE3AKDRALKPDGFRB | |
| SCHEMBL5988631 | 0.79 | PDGFRB (0.40) | PDE3BPDE3AKDRALKPDGFRB | |
| SCHEMBL5991041 | 0.78 | PDE3B (0.45) | PDE3BPDE3AKDRALKPDGFRB | |
| SCHEMBL5989181 | 0.78 | EGFR (0.51) | PDE3BPDE3A | |
| SCHEMBL5991013 | 0.77 | PDE3B (0.42) | PDE3BPDE3AALKABL1RET | |
| SCHEMBL5989414 | 0.77 | PDE3B (0.42) | PDE3BPDE3A | |
| SCHEMBL6390720 | 0.76 | PDGFRB (0.58) | KDRALKPDGFRBABL1RET | |
| SCHEMBL5988083 | 0.76 | KDR (0.36) | KDRALKPDGFRBABL1RET | |
| SCHEMBL5988454 | 0.75 | KDR (0.44) | KDRALKPDGFRBABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |