Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989352 | 0.93 | DYRK3 (0.43) | DYRK3PRKD3MAP4K4ERBB2PIM1 | |
| SCHEMBL989394 | 0.89 | DYRK3 (0.46) | DYRK3PRKD3MAP4K4ERBB2PIM1 | |
| SCHEMBL26981862 | 0.75 | TLR8 (0.39) | DYRK3PRKD3MAP4K4ERBB2PIM1 | |
| SCHEMBL27130458 | 0.75 | TLR8 (0.39) | DYRK3PRKD3MAP4K4ERBB2PIM1 | |
| SCHEMBL29844411 | 0.75 | TLR8 (0.39) | DYRK3PRKD3MAP4K4ERBB2PIM1 | |
| SCHEMBL9952969 | 0.71 | DPP4 (0.51) | KMT2ATSHR | |
| SCHEMBL14247443 | 0.71 | KMT2A (0.47) | CYP1A2CYP2D6TLR8KMT2AHTT | |
| SCHEMBL21311044 | 0.70 | TLR8 (0.41) | MAPK14CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL989490 | 0.70 | DYRK3 (0.42) | DYRK3PRKD3MAP4K4ERBB2PIM1 | |
| SCHEMBL989488 | 0.70 | DYRK3 (0.42) | DYRK3PRKD3MAP4K4ERBB2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720862-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005080380-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |