SCHEMBL5989445

SCHEMBL5989445

N#Cc1cccc(NCC(N)=O)c1C#N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
GAA P10253 6/20 0.39
KDM4E B2RXH2 5/20 0.39
TSHR P16473 2/20 0.38
CXCR2 P25025 1/20 0.38
MELK Q14680 1/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
ALOX15 P16050 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GLA P06280 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28563798 0.79 GAA (0.49) ALDH1A1GAAKDM4ETSHRCXCR2
SCHEMBL6826559 0.79 NLRP3 (0.54) ALDH1A1POLBMAPTGAAKDM4E
SCHEMBL10330186 0.75 TSHR (0.43) ALDH1A1GAAKDM4ETSHRHSD17B10
Oxalic Acid SCHEMBL20984691 0.74 GAA (0.44) ALDH1A1GAAKDM4ETSHRCXCR2
Oxalic Acid SCHEMBL20984690 0.74 GAA (0.44) ALDH1A1GAAKDM4ETSHRCXCR2
SCHEMBL976427 0.74 PIP4K2A (0.39) ALDH1A1MAPTGAAKDM4ETSHR
SCHEMBL5026903 0.72 F2 (0.36) ALDH1A1POLBMAPTGAAKDM4E
Sulfuric Acid SCHEMBL20984255 0.71 CA12 (0.40) ALDH1A1GAAKDM4ETSHRCXCR2
Phosphoric Acid SCHEMBL20984674 0.71 GAA (0.37) ALDH1A1GAAKDM4ETSHRCXCR2
SCHEMBL10330188 0.71 KDM4E (0.75) ALDH1A1POLBMAPTGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1725522-A1 ANILINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2006-11-29 EP disclosed
WO-2005085185-A1 ANILINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2005-09-15 WO disclosed