Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.77 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13416529 | 0.87 | S1PR1 (1.00) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL13524983 | 0.85 | S1PR1 (0.78) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL14195593 | 0.84 | S1PR1 (0.72) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL5953007 | 0.82 | S1PR1 (0.51) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL1413283 | 0.81 | S1PR1 (0.88) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL1402234 | 0.81 | S1PR1 (0.70) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL436150 | 0.81 | S1PR1 (1.00) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL29389224 | 0.81 | S1PR1 (1.00) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL13960100 | 0.80 | S1PR1 (0.80) | S1PR1S1PR5ALOX15S1PR3S1PR4 | |
| SCHEMBL24161900 | 0.80 | S1PR1 (0.80) | S1PR1S1PR5ALOX15S1PR3S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173710-B2 | Bicyclic sphingosine 1-phosphate analogs | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110195936-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-08-11 | — | — | US | disclosed |
| US-7964649-B2 | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-21 | — | — | US | disclosed |
| US-7964649-B2 | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-21 | — | — | US | disclosed |
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2011-05-05 | — | — | US | disclosed |
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-23 | — | — | US | disclosed |
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-23 | — | — | US | disclosed |
| US-7786173-B2 | Tetralin analogs having sphingosine 1-phosphate agonist activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-08-31 | — | — | US | disclosed |
| US-20090253760-A1 | HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090253760-A1 | HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090105315-A1 | PHENYL-CYCLOALKYL AND PHENYL-HETEROCYCLIC DERIVATIVES AS S1P RECEPTOR AGONISTS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-04-23 | — | — | US | disclosed |
| US-20090105315-A1 | PHENYL-CYCLOALKYL AND PHENYL-HETEROCYCLIC DERIVATIVES AS S1P RECEPTOR AGONISTS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-04-23 | — | — | US | disclosed |
| US-20090042955-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-02-12 | — | — | US | disclosed |
| US-20090042955-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-02-12 | — | — | US | disclosed |
| US-7351725-B2 | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-7309721-B2 | Immunosuppressants for treating diseases and conditions of bone marrow, organ and tissue transplant rejection; chemotherapeutic drug for cancers; antiinflammatory agents for rheumatoid arthritis; activate the production of lymphocyte; 2-Amino-4-(4-(octylphenyl))butanol, O-phosphate | MERCK + CO., INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-7220734-B2 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2007-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253760-A1 | HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR5 5/4885ALOX15 2950/4885 |
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | SPHK2, SPHK1, S1PR2 | S1PR1 5/4885S1PR5 6/4885ALOX15 1890/4885 |
| US-20090105315-A1 | PHENYL-CYCLOALKYL AND PHENYL-HETEROCYCLIC DERIVATIVES AS S1P RECEPTOR AGONISTS | S1PR1, S1PR3, S1PR4 | S1PR1 1/4885S1PR5 5/4885ALOX15 2122/4885 |
| US-20090042955-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR5 5/4885ALOX15 2800/4885 |
| US-20110195936-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR5 5/4885ALOX15 2800/4885 |
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR5 5/4885ALOX15 2800/4885 |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | S1PR1, S1PR4, S1PR2 | S1PR1 1/4885S1PR5 5/4885ALOX15 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.