Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886544 | 0.91 | MEN1 (0.45) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL5763796 | 0.87 | IDO1 (0.52) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL5988682 | 0.85 | MEN1 (0.45) | MEN1KMT2ATDP1IDO1MAPK1 | |
| SCHEMBL7115809 | 0.85 | MEN1 (0.43) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL6137927 | 0.82 | IDO1 (0.40) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL4851861 | 0.81 | MEN1 (0.60) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL27583342 | 0.79 | MEN1 (0.43) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL27583344 | 0.79 | MEN1 (0.43) | MEN1KMT2ATDP1IDO1GFER | |
| SCHEMBL1038046 | 0.79 | MAPT (0.42) | MEN1KMT2AGFERSMN1; SMN2MAPK1 | |
| SCHEMBL5988793 | 0.79 | MEN1 (0.71) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030119-B1 | Method for treating chronic pain using MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-04-18 | — | — | US | claimed |
| CN-1358094-A | Methods of treating chronic pain with MEK inhibitors | WARNER LAMBERT CO (US) | 2002-07-10 | — | — | CN | claimed |
| US-7030119-B1 | Method for treating chronic pain using MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1144385-B1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-08-17 | — | — | EP | disclosed |
| US-6469004-B1 | Benzoheterocycles and their uses as MEK inhibitors | WARNER-LAMBERT COMPANY | 2002-10-22 | — | — | US | disclosed |
| CN-1358094-A | Methods of treating chronic pain with MEK inhibitors | WARNER LAMBERT CO (US) | 2002-07-10 | — | — | CN | disclosed |
| EP-1202731-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1144385-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005390-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000042022-A1 | BENZOHETEROCYCLES AND THEIR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |