Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988253 | 0.87 | IDO1 (0.47) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL5990169 | 0.85 | MEN1 (0.43) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL4851861 | 0.81 | MEN1 (0.60) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL5741582 | 0.80 | MAP2K1 (0.49) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL14590716 | 0.80 | MAP2K1 (0.47) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL1040434 | 0.79 | NR4A2 (0.40) | MEN1KMT2AMAP2K1GFERSMN1; SMN2 | |
| SCHEMBL1077501 | 0.79 | MAPT (0.41) | MEN1KMT2AMAP2K1MAP2K2GFER | |
| SCHEMBL3862123 | 0.79 | MEN1 (0.71) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL4854904 | 0.79 | MEN1 (0.50) | MEN1KMT2ATDP1IDO1MAP2K1 | |
| SCHEMBL4860826 | 0.79 | MEN1 (0.50) | MEN1KMT2ATDP1IDO1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504398-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202731-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005390-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| EP-1202731-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005390-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |