Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13843439 | 0.95 | PRMT5 (0.36) | PRMT5WDR77L3MBTL1JAK2JAK1 | |
| SCHEMBL4558219 | 0.93 | L3MBTL1 (0.37) | L3MBTL1JAK2JAK1KDM4EALDH1A1 | |
| SCHEMBL13843282 | 0.87 | L3MBTL1 (0.36) | PRMT5WDR77L3MBTL1JAK2JAK1 | |
| SCHEMBL13783374 | 0.85 | L3MBTL1 (0.34) | PRMT5WDR77L3MBTL1JAK2JAK1 | |
| SCHEMBL4558848 | 0.85 | L3MBTL1 (0.37) | L3MBTL1JAK2JAK1KDM4EGAA | |
| SCHEMBL13783368 | 0.84 | L3MBTL1 (0.38) | L3MBTL1JAK2JAK1KDM4EGAA | |
| SCHEMBL13783363 | 0.83 | L3MBTL1 (0.37) | L3MBTL1JAK2JAK1KDM4EGAA | |
| SCHEMBL13783364 | 0.83 | L3MBTL1 (0.37) | L3MBTL1JAK2JAK1KDM4EGAA | |
| SCHEMBL13783618 | 0.82 | L3MBTL1 (0.37) | L3MBTL1JAK2JAK1KDM4EALDH1A1 | |
| SCHEMBL13783382 | 0.82 | L3MBTL1 (0.37) | L3MBTL1JAK2JAK1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1661896-A1 | PYRROLOPYRIMIDINETHIONE DERIVATIVE | Teijin Pharma Limited (JP) | 2006-05-31 | — | — | EP | disclosed |