Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31256743 | 0.79 | ESR1 (0.54) | ESR1ESR2HSP90AA1HIF1AAHR | |
| SCHEMBL14261867 | 0.79 | ESR1 (0.72) | ESR1ESR2HSP90AA1MEN1HPGD | |
| SCHEMBL5989215 | 0.79 | KAT6A (0.55) | ESR1ESR2HIF1AMEN1MAPT | |
| SCHEMBL6714356 | 0.76 | ESR1 (0.50) | ESR1ESR2HSP90AA1HIF1ALMNA | |
| SCHEMBL28635711 | 0.75 | PTGS1 (0.55) | ESR1ESR2EPHX2HIF1AMAPT | |
| SCHEMBL4933522 | 0.75 | ESR1 (0.72) | ESR1ESR2HSP90AA1 | |
| SCHEMBL4931111 | 0.75 | ESR1 (1.00) | ESR1ESR2HSP90AA1MEN1HPGD | |
| SCHEMBL7125896 | 0.72 | ESR1 (0.49) | ESR1ESR2HSP90AA1HIF1ALMNA | |
| SCHEMBL24073251 | 0.72 | AHR (0.47) | EPHX2LMNAMEN1MAPTHPGD | |
| SCHEMBL21185992 | 0.72 | CDK9 (0.41) | HSP90AA1EPHX2LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |