Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.46 |
| ▸ | USP7 | Q93009 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599267 | 1.00 | IDO1 (0.50) | IDO1GRM5HCRTR1HCRTR2USP7 | |
| SCHEMBL599268 | 1.00 | IDO1 (0.50) | IDO1GRM5HCRTR1HCRTR2USP7 | |
| SCHEMBL599430 | 0.89 | HCRTR1 (0.49) | IDO1GRM5HCRTR1HCRTR2USP7 | |
| SCHEMBL601360 | 0.89 | HCRTR1 (0.49) | IDO1GRM5HCRTR1HCRTR2USP7 | |
| SCHEMBL7879741 | 0.85 | GRM5 (0.51) | IDO1GRM5HCRTR1HCRTR2USP7 | |
| SCHEMBL600383 | 0.85 | HCRTR1 (0.43) | IDO1HCRTR1HCRTR2 | |
| SCHEMBL30794584 | 0.82 | GRM5 (0.46) | IDO1GRM5HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL599401 | 0.82 | GRM5 (0.46) | IDO1GRM5HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL10189494 | 0.79 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL601120 | 0.79 | HCRTR1 (0.45) | IDO1HCRTR1HCRTR2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040998-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCER SWATI P (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040998-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | GRM5, GRIK5, GRM2 | IDO1 3079/4885GRM5 1/4885HCRTR1 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.